| CAS NO: | 621-42-1 |
| 包装 | 价格(元) |
| 25 g | 电议 |
| 50 g | 电议 |
| 100 g | 电议 |
| 500 g | 电议 |
| Cas No. | 621-42-1 |
| 别名 | N-(3-羟基苯基)乙酰胺 |
| Canonical SMILES | O=C(C)NC1=CC(O)=CC=C1 |
| 分子式 | C8H9NO2 |
| 分子量 | 151.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Metacetamol is a derivative of acetaminophen .1,2,3Unlike acetaminophen, metacetamol is not cytotoxic to isolated mouse hepatocytes (LC50= >10 mM).1However, it does induce necrosis and depletion of glutathione (GSH) in isolated human hepatocytes when used at a concentration of 10 mM.2Metacetamol (900 mg/kg) does not induce hepatic necrosis in mice.3 1.Holme, J.A., Hongslo, J.K., BjØrge, C., et al.Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytesBiochem. Pharmacol.42(5)1137-1142(1991) 2.Xie, Y., McGill, M.R., Du, K., et al.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytesToxicol. Appl. Pharmacol.289(2)213-222(2015) 3.Nelson, E.B.The pharmacology and toxicology of meta-substituted acetanilide I: Acute toxicity of 3-hydroxyacetanilide in miceRes. Commun. Chem. Pathol. Pharmacol.28(3)447-456(1980) |
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