| CAS NO: | 1246815-11-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1246815-11-1 |
| 别名 | 消旋卡多曲杂质,Acetorphan-d5 |
| Canonical SMILES | [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1COC(CNC(C(CSC(C)=O)CC2=CC=CC=C2)=O)=O |
| 分子式 | C21H18D5NO4S |
| 分子量 | 390.5 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Racecadotril-d5is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan .1,2In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively.1It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea.2Formulations containing racecadotril have been used in the treatment of acute diarrhea. 1.Griggs, D.W., Prinsen, M.J., Oliva, J., et al.Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrheaJ. Pharmacol. Exp. Ther.357(2)423-431(2016) 2.Bui, T., Li, G., Kim, I., et al.Effects of racecadotril on weight loss and diarrhea due to human rotavirus in neonatal gnotobiotic pigs (Sus scrofa domesticus)Comp. Med.67(2)157-164(2017) |
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