| CAS NO: | 5370-34-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 5370-34-3 |
| Canonical SMILES | OC(CCC1=C(C)C(C[C@@H]2NC([C@H](CC)[C@H]2C)=O)=N/C1=C\C3=C(CCC(O)=O)C(C)=C(C[C@@H]4NC([C@H](C)[C@H]4CC)=O)N3)=O.Cl |
| 分子式 | C33H46N4O6 • XHCl |
| 分子量 | 594.8 |
| 溶解度 | DMF: soluble,NaOH (aq): soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Stercobilin is a fecal pigment and a metabolite of the heme catabolite bilirubin .1It induces DNA damage in a comet assay in HepG2 cells when used at concentrations ranging from 0.5 to 17 µM.2Stercobilin (20 and 30 µM) induces activation of NF-κB in a reporter assay and increases the expression of the genes encoding TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS), and COX-2 in RAW 264.7 macrophages.3Fecal and plasma levels of stercobilin are increased inob/obmice. 1.VÍtek, L., Majer, F., MuchovÁ, L., et al.Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal floraJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.833(2)149-157(2006) 2.MÖlzer, C., Pfleger, B., Putz, E., et al.In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cellsExp. Cell Res.319(4)536-545(2013) 3.Sanada, S., Suzuki, T., Nagata, A., et al.Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob miceSci. Rep.10(1)6479(2020) |
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