| CAS NO: | 864070-37-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 864070-37-1 |
| 别名 | 达格列净杂质 |
| Canonical SMILES | O[C@H]([C@H]1O)[C@H](C(C=C2)=CC(CC(C=C3)=CC=C3O)=C2Cl)O[C@@H]([C@H]1O)CO |
| 分子式 | C19H21ClO6 |
| 分子量 | 380.8 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | O-desethyl Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50= 9.4 nM) and active metabolite of dapagliflozin .1,2It is selective for SGLT2 over SGLT1 (IC50= 970 nM).1 1.Xu, B., Feng, Y., Cheng, H., et al.C-aryl glucosides substituted at the 4’-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetesBioorg. Med. Chem. Lett.21(15)4465-4470(2011) 2.Xu, G., Lv, B., Roberge, J.Y., et al.Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetesJ. Med. Chem.57(4)1236-1251(2014) |
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