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(±)-N-desmethyl Venlafaxine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-N-desmethyl Venlafaxine(hydrochloride)图片
CAS NO:93413-90-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A minor active metabolite of venlafaxine
Cas No.93413-90-2
别名盐酸文拉法辛杂质D
Canonical SMILESCOC(C=C1)=CC=C1C(CNC)C2(O)CCCCC2.Cl
分子式C16H25NO2 • HCl
分子量299.8
溶解度Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.1It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.2(±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).1In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.

1.Muth, E.A., Moyer, J.A., Haskins, J.T., et al.Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxineDrug Dev. Res.23(2)191-199(1991) 2.Otton, S.V., Ball, S.E., Cheung, S.W., et al.Venlafaxine oxidation in vitro is catalysed by CYP2D6Br. J. Clin. Pharmacol.41(2)149-156(1996)