| CAS NO: | 83356-60-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 83356-60-9 |
| 别名 | 艾司洛尔酸钠 |
| Canonical SMILES | O=C(CCC1=CC=C(C=C1)OCC(CNC(C)C)O)O.Cl |
| 分子式 | C15H23NO4 • HCl |
| 分子量 | 317.8 |
| 溶解度 | DMF: insol,DMSO: insol,Ethanol: insol,PBS (pH 7.2): 5 mg/ml |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Esmolol acid is an active metabolite of the β1-adrenergic receptor (β1-AR) antagonist esmolol .1It is formed from esmololviahydrolysis by a red blood cell esterase. Esmolol acid inhibits isoproterenol-induced increases in the beating rate of isolated guinea pig right atria (pA2= 3.73) and prevents tachycardia and hypotension induced by isoproterenol in anesthetized dogs in a dose-dependent manner.2It is also a potential impurity in commercial preparations of esmolol.3 1.Jahn, P., Eckrich, B., Schneidrowski, B., et al.β1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man. Investigations using tricresylphosphate as red blood cell carboxylesterase inhibitorArzneimittelforschung45(5)536-541(1995) 2.Shaffer, J.E., Quon, C.Y., and Gorczynski, R.J.β-adrenoreceptor antagonist potency and pharmacodynamics of ASL-8123, the primary acid metabolite of esmololJ. Cardiovasc. Pharmacol.11(2)187-192(1988) 3.Sahadev Reddy, M., Reddy, M.S.N., Rajan, S.T., et al.Structural identification and characterization of impurities in esmolol hydrochlorideDer Pharma Chem.8(4)296-300(2016) |
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