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11-Dehydrocorticosterone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
11-Dehydrocorticosterone图片
CAS NO:72-23-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
11-脱氢皮质酮是一种内源性皮质类固醇。
Cas No.72-23-1
别名11-去氫皮質甾酮,11-DHC
化学名21-hydroxy-pregn-4-ene-3,11,20-trione
Canonical SMILESC[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(CO)=O)C
分子式C21H28O4
分子量344.4
溶解度Chloroform: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

11-Dehydrocorticosterone is an endogenous mineralocorticoid.[1],[2],[3] It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner.[1],[2] 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone .[3] Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.[4]

Reference:
[1].Muto, S., Nemoto, J., Ebata, S., et al.Corticosterone and 11-dehydrocorticosterone stimulate Na,K-ATPase gene expression in vascular smooth muscle cellsKidney Int.54(2)492-508(1998)
[2].Brem, A.S., Matheson, K.L., Barnes, J.L., et al.11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladderAm. J. Physiol.261(5)F873-F879(1991)
[3].Souness, G.W., and Morris, D.J.11-Dehydrocorticosterone in the presence of carbenoxolone is a more potent sodium retainer than corticosteroneSteroids58(1)24-28(1993)
[4].Harno, E., Cottrell, E.C., Keevil, B.G., et al.11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male miceEndocrinology154(10)3599-3609(2013)