| CAS NO: | 195875-84-4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 195875-84-4 |
| 别名 | 特索芬辛,NS-2330 |
| Canonical SMILES | CN1[C@@H]2C[C@H](C3=CC(Cl)=C(Cl)C=C3)[C@@H](COCC)[C@H]1CC2 |
| 分子式 | C17H23Cl2NO |
| 分子量 | 328.3 |
| 溶解度 | DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tesofensine is a triple monoamine reuptake inhibitor that inhibits norepinephrine, serotonin (5-HT), and dopamine reuptake function.1,2In vivo, tesofensine (2 mg/kg, s.c.) reduces body weight and food intake in a rat model of high-fat diet-induced obesity.1 1.Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H.Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese ratNeuropsychopharmacology35(7)1464-1476(2010) 2.van de Giessen, E., de Bruin, K., la Fleur, S.E., et al.Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese ratsEur. Neuropsychopharmacol.22(4)290-299(2012) |
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