Dimethindene maleate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

3614-69-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Dimethindene maleate 是一种选择性的 histamine H1 拮抗剂，具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。

Cas No.

3614-69-5

分子式

C₂₄H₂₈N₂O₄

分子量

408.49

储存条件

Store at -20°C, protect from light, stored under nitrogen

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Dimethindene maleate is a selectivehistamine H1antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions^[1]^[2]^[3].

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K^＋currents in a concentration-dependent and reversible manner with an IC₅₀value of 29.5 μM^[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K^＋currents with an IC₅₀value of 49 μM^[2].

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice^[1].

Animal Model:	C57BL/6 mice with wound healing^[1]
Dosage:	0.25 mg
Administration:	Intraperitoneal injection; 0.25 mg once
Result:	Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.