SAE-14

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SAE-14

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1241280-25-0

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂，IC50值为 28.5 nM，可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导， IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。

Cas No.

1241280-25-0

别名

GPR183 antagonist-1

分子式

C₁₉H₁₉F₃N₂O₂

分子量

364.36

溶解度

DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

IC50: 28.5 nM (GPR183)^[1]

SAE-14 (compound SAE-14) is a potent, specificGPR183antagonist with anIC₅₀value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization withIC₅₀value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice^[1].

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC-induced calcium mobilization with an IC₅₀value below 50 nM^[1].

Cell Viability Assay^[1]

Cell Line:	The human leukemia (HL)-60 cells
Concentration:	5×of the antagonist
Incubation Time:	15 min
Result:	Had GPR183-specific (IC₅₀: 28.5nM) and abolished 7a, 25-OHC-induced calcium mobilization in the HL-60 cells.

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice^[1].

Animal Model:	Male and female ICR mice^[1]
Dosage:	2.9 µM
Administration:	intrathecal (i.th.) injections; 2.9 µM; once
Result:	Reversed CCI-induced mechanical allodynia in a time-dependent manner.