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Indium(III)thiosemicarbazone 5b
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Indium(III)thiosemicarbazone 5b图片
CAS NO:2345755-20-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An anticancer agent
Cas No.2345755-20-4
Canonical SMILES[Cl-][In+3]12([O-]C)([S]=C([N](C)C)[NH][N]1=CC3=CC=CC=[N]32)[Cl-]
分子式C10H15Cl2InN4OS
分子量425
溶解度DMF: 10 mg/mL,DMF:PBS (pH 7.2) (1:2): 0.30 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly Soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Indium (III) thiosemicarbazone 5b is an anticancer agent.1It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells.In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.

1.Jiang, M., Chu, Y., Yang, T., et al.Developing a novel indium(III) agent based on liposomes to overcome cisplatin-induced resistance in breast cancer by multitargeting the tumor microenvironment componentsJ. Med. Chem.64(19)14587-14602(2021)