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Cyclo(L-Phe-L-Pro)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclo(L-Phe-L-Pro)图片
CAS NO:3705-26-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Cyclo(L-Phe-L-Pro) 可从 Pseudomonas fluorescens 和 Pseudomonas alcaligenes 无细胞培养上清液中分离得到，是一种抗真菌环状二肽。Cyclo(L-Phe-L-Pro)通过干扰视黄酸诱导基因-I (RIG-I) 的激活来抑制 IFN-β 产生。Cyclo(L-Phe-L-Pro) 还具有自由基清除活性，IC50 为 24 µM。
Cas No.3705-26-8
别名环(PHE-PRO)
分子式C14H16N2O2
分子量244.29
溶解度DMSO : 250 mg/mL (1023.37 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].

[1]. Katrin StrÖm, et al. Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7.
[2]. Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.
[3]. Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.