SPHINX

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SPHINX

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

848057-98-7

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议

产品介绍

SPHINX 是 SRPK1 的选择性抑制剂，IC50 值为 0.58 μM。SPHINX 有效地减少体内脉络膜新生血管 (CNV)。SPHINX 可用于老年性黄斑变性的研究。

Cas No.

848057-98-7

分子式

C₁₇H₁₇F₃N₂O₃

分子量

354.32

溶解度

DMSO : 50 mg/mL (141.12 mM; ultrasonic and warming and heat to 60°C)

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

IC50: 0.58 μM (SRPK1)^[1]

SPHINX is a selectiveSRPK1inhibitor with anIC₅₀value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD^[1].

SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2^[1].
SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines^[1].

Western Blot Analysis^[1]

Cell Line:	ARPE-19 cell line
Concentration:	10 μM
Incubation Time:	2 hours
Result:	Blocked EGF-induced phosphorylation of SRSF1 and SRSF2.

SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo^[1].
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats^[1].

Animal Model:	C57/B6 mice with laser-induced CNV^[1]
Dosage:	10 ng
Administration:	Intraocular injection; 10 ng on laser photocoagulation day 0 and day 7
Result:	Significantly reduced neovascular growth compared with saline-injected controls.

Animal Model:	Norway Brown rats with laser-induced choroidal neovascularization^[1]
Dosage:	25 ng (10 ng/uL)
Administration:	Intraocular injection; 25 ng (10 ng/uL) on laser photocoagulation day 0 and day 7
Result:	Significantly reduced the CNV area compared with saline injected controls.