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MOMIPP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MOMIPP图片
CAS NO:1363421-46-8
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
MOMIPP，一种巨胞饮作用的诱导剂，是一种 PIKfyve 抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。
Cas No.1363421-46-8
分子式C18H16N2O2
分子量292.33
溶解度DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MOMIPP, a macropinocytosis inducer, is aPIKfyveinhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].

Western Blot Analysis[2]

Cell Line:U251 cells
Concentration:10 μM
Incubation Time:4 h or 24 h
Result:Activated the JNK stress kinase pathway.

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].

Animal Model:Athymic CrTac:NCR-Foxn1mice (female, 7-8 weeks)[2]
Dosage:80 mg/kg
Administration:i.p.; once daily; for 15 consecutive days
Result:Suppressed progression of intracerebral glioblastoma xenografts.