Indimitecan

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Indimitecan

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

915360-05-3

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议

产品介绍

Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。

Cas No.

915360-05-3

别名

LMP776

分子式

C₂₅H₂₁N₃O₆

分子量

459.45

溶解度

DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities^[1].

Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM^[1].
Indimitecan shows potent DNA cleavage due to Top1 inhibition^[1].
Indimitecan can be substrates for metabolic ketone reductases^[1].

Cell Proliferation Assay^[1]

Cell Line:	HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7
Concentration:	0-100 μM
Incubation Time:
Result:	Showed growth inhibition with GI₅₀s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute's developmental therapeutics assay (the "NCI60")) was 0.079 ± 0.023 μM.