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CVT-11127
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CVT-11127图片
CAS NO:1018674-83-3
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
CVT-11127 是一种有效的 SCD 抑制剂。CVT-11127 诱导细胞凋亡 apoposis 并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。
Cas No.1018674-83-3
别名GS-456332
分子式C25H23Cl2N5O3
分子量512.39
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CVT-11127 is a potentSCDinhibitor. CVT-11127 inducesapoposisand arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

Cell Proliferation Assay[1]

Cell Line:H460 cells
Concentration:1 µM
Incubation Time:48 h
Result:Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line:H460 cells
Concentration:1 µM
Incubation Time:48 h
Result:Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line:H460 cells
Concentration:1 µM
Incubation Time:24 h
Result:Induced apoposis H460 cells.