| CAS NO: | 1404019-95-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 1404019-95-9 |
| 别名 | SAR339375; RG-012 |
| 分子量 | 6429.3 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lademirsen (SAR339375; RG-012) is a single stranded, chemically modified oligonucleotide that binds to and inhibits the function of miR-21. Lademirsen has the potential for Alport nephropathy research[1][2]. Administration of Lademirsen (SAR339375; RG-012) to inhibit miR-21 leads to a slowed progression of renal fibrosis and an increased lifespan in Alport syndrome mouse models[1]. [1]. Ivan G Gomez, et al. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest. 2015 Jan;125(1):141-56. |
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