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RGD Peptide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RGD Peptide图片
CAS NO:114681-65-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
RGD Peptide 作为整合素-配体相互作用的抑制剂，在细胞粘附、迁移、生长和分化中起重要作用。
Cas No.114681-65-1
别名H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH
Canonical SMILESNCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(O)=O)=O)=O)=O)=O)=O
分子式C23H38N10O10
分子量614.6
溶解度DMF: 14 mg/ml,DMSO: 5 mg/ml,PBS (pH 7.2): 0.33 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RGD peptide is a synthetic compound made up of the arginine-glycine-aspartate motif that has been extensively used to inhibit integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.1RGD peptide has also been shown to directly induce apoptosis, independent of integrin-mediated cell clustering or signals, by initiating conformational changes that enhance pro-caspase-3 activation and autoprocessing.2,3

1.Ruoslahti, E., and Öbrink, B.Common principles in cell adhesionExp. Cell Res.2271-11(1996) 2.Buckley, C.D., Pilling, D., Henriquez, N.V., et al.RGD peptides induce apoptosis by direct caspase-3 activationNature397534-539(1999) 3.Adderley, S.R., and Fitzgerald, D.J.Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activationJ. Biol. Chem.2755760-5766(2000)