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UCB-5307
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UCB-5307图片
CAS NO:1515887-44-1
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
UCB-5307 是一种 TNF 抑制剂，对人 TNFα 的 KD 为 9 nM。UCB-5307 可以穿透预制的 hTNF/hTNFR1 复合物。
Cas No.1515887-44-1
分子式C22H21N3O
分子量343.42
溶解度DMSO : 50 mg/mL (145.59 mM; Need ultrasonic)
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UCB-5307 is a potentTNFsignaling inhibitor with aKDof 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1].

UCB-5307 inhibits wild-type TNF but does not inhibit L57F TNF. The T1/2of UCB-5307 is 3.3 h[1].
UCB-5307 disrupts a preformed hTNF/hTNFR1 complex, can penetrate the preformed complex, dislodging one of the receptors. Preloading hTNF with UCB-5307 blocks one receptor from binding[1].
UCB-5307 binds to a pocket in the centre of the TNF trimer formed by the movement of the TNF monomers, stabilising the distorted trimer, which leads to reduced signalling through TNFR1[1].