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Dabrafenib Mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dabrafenib Mesylate图片
CAS NO:1195768-06-9
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品名称
GSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B
产品介绍

生物活性

Dabrafenib Mesylate是一种新颖,有效和选择性的Raf激酶抑制剂,能够抑制野生型B-Raf,B-RafV600E和c-Raf的激酶活性,IC50值分别为3.2、0.8和5.0 nM。

化学数据

目录号A15059
作用机制Inhibitor (抑制剂)
M. Wt615.67
FormulaC24H24F3N5O5S3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1195768-06-9
SynonymsGSK-2118436 Mesylate, GSK2118436 Mesylate, GSK 2118436 Mesylate, GSK 2118436B
SMILESCC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O

溶解度

In vitroDMSO96 mg/mL (155.92 mM)
WaterInsoluble
Ethanol5 mg/mL (8.12 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.24 mL81.21 mL162.42 mL
0.5 mM3.25 mL16.24 mL32.48 mL
1 mM1.62 mL8.12 mL16.24 mL
5 mM0.32 mL1.62 mL3.25 mL

*The above data is based on the productmolecular weight 615.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.