C16 (GW-506033X; C-16; PKR Inhibitor) is a brain penetrant protein kinase (PKR) inhibitor with anti-inflammatory effects. The double-stranded RNA-dependent protein kinase (PKR), an apoptotic inducer, regulates much pro-inflammatory cytokine production. It binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 =186-210 nM). It can decrease Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures, and prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model.

纯度：≥98%

CAS：608512-97-6