Durlobactam sodium (ETX-2514 sodium, ETX 2514) is a broad-spectrum β-lactamase inhibitor used for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. ETX2514 broadly inhibits Ambler class A, C, and D β-lactamases. ETX2514 combined with sulbactam (SUL) in vitro restores sulbactam activity against Acinetobacter baumannii ETX2514-sulbactam (ETX2514SUL) is under development for the treatment of A. baumannii infections. ETX2514 restored β-lactam activity to equal potency against isogenic Pseudomonas aeruginosa strains each overexpressing one of the 10 β-lactamases.

纯度：≥98%

CAS：1467157-21-6