Tegobuvir (GS-9190; GS-333126) is a novel and potent non-nucleoside polymerase/HCV NS5B polymerase inhibitor with antiviral effects. Tegobuvir (GS-9190) exhibited EC(50)s of <16 nM against genotype 1 and >100 nM for other genotypes tested. Tegobuvir is highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance. GS-9190 represents a novel class of nonnucleoside polymerase inhibitors that interact with NS5B likely through involvement of the β-hairpin in the thumb subdomain.

纯度：≥98%

CAS：1000787-75-6