Larotaxel (XRP9881) is a semi-synthetic taxane analogue with potential antineoplastic activities and preclinical activity against taxane-resistant breast cancer. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

纯度：≥98%

CAS：156294-36-9