ML418 is a selective and brain-penetrant pore blocker of Kir7.1 potassium channel (IC50, 310 nM). The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy.

纯度：≥98%

CAS：1928763-08-9