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PX-478 HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PX-478 HCl图片
CAS NO:685898-44-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

PX-478 HCl是HIF-1alpha抑制剂,也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性,可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子,具有良好的i.v.,i.p.和p.o.抗肿瘤活性。

靶点信息

HIF-1α

化学数据

目录号A14319
作用机制Inhibitor (抑制剂)
M. Wt394.12
FormulaC13H20Cl4N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.685898-44-6
Synonyms0
SMILESC1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

溶解度

In vitroDMSO73 mg/mL (185.21 mM)
Water73 mg/mL (185.21 mM)
Ethanol73 mg/mL (185.21 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.37 mL126.86 mL253.73 mL
0.5 mM5.07 mL25.37 mL50.75 mL
1 mM2.54 mL12.69 mL25.37 mL
5 mM0.51 mL2.54 mL5.07 mL

*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.