UK122 是一种有效的，选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，IC50 为 0.2 μM。UK122 对组织型 PA (tPA)、纤溶酶、凝血酶和胰蛋白酶没有或几乎没有抑制作用(IC50>100 μM)。UK122 是 4-恶唑烷酮类似物，一种抗癌剂，可抑制癌细胞迁移和侵袭。
货号:ajcx36176
CAS:940290-58-4
分子式:C17H13N3O2
分子量：291.3
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].

UK122 (11.1, 33.3, 100 μM; 24 h) dose-dependently inhibits cell migration and significantly reduces the invasiveness of CFPAC-1 cells[1]. UK122 (10-100 μM; 48 h) has no effect of any cell growth or cell morphology change in CFPAC-1 cells[1].

[1]. Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.