Subasumstat (TAK-981) 是首创的、SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤活性。
货号:ajcx38662
CAS:1858276-04-6
分子式:C25H28ClN5O5S2
分子量：578.1
溶解度:DMSO : 16.67 mg/mL (28.84 mM; ultrasonic and warming and heat to 80°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Subasumstat (TAK-981) is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities[1][2].

Subasumstat (TAK-981) is able to increase the production of type 1 IFN, thereby increasing type 1 IFN-mediated signaling, activating innate effector cells and enhancing the antitumor innate immune responses[1].

A single sub-cutaneous injection of Subasumstat (TAK-981) in naive Balb/c mice at the brachial lymph nodes induces activation of DCs[2].

[1]. Sumoylation inhibitor TAK-981.
[2]. TAK-981.