PROTAC FLT-3 degrader 1 是基于 von Hippel-Lindau 的 FLT-3内部串联重复 (ITD) 降解剂 PROTAC，IC50为0.6 nM。抗增殖，诱导凋亡活性。
货号:ajcx39810
CAS:2230826-81-8
分子式:C52H61N9O9S2
分子量：1020.23
溶解度:DMSO : 150 mg/mL (147.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.