M4 mAChR agonist-1 (compound 10a) 是一种有效的 M4 mAChR 激动剂，对人 M4 的 IC50 >10 μM。
货号:ajcx39832
CAS:785705-53-5
分子式:C14H18N4OS
分子量：290.38
溶解度:DMSO : 20 mg/mL (68.88 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 70°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4[1].

[1]. Wood MR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2016;26(13):3029-3033.