Targapremir-210是有效的miR-210抑制剂，作用于MDA-MB-231细胞系的IC50值为200nM。Targapremir-210通过和miR-210的发夹前体结构结合，进而抑制miRNA的成熟。
货号:ajcx12814
CAS:1049722-30-6
分子式:C32H36N10O2
分子量：592.69
溶解度:DMSO: 250 mg/mL (421.81 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.

[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.