CYM 2503 是一种推定的 GalR2 阳性变构调节剂。
货号:ajcx26460
CAS:1308833-36-4
分子式:C45H55N5O7
分子量：778
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CYM 2503 is a positive allosteric modulator (PAM) of the galanin-2 (GAL₂) receptor.¹It enhances the production of inositol monophosphate (IP₁) induced by galanin in HEK293 cells expressing the GAL₂receptor (EC₅₀= 0.69 µM). CYM 2503 (60 mg/kg) increases the latency to first electrographic and behavioral seizures and reduces mortality in a lithium-pilocarpine (Li-pilocarpine) rat model of status epilepticus.

1.Lu, X., Roberts, E., Xia, F., et al.GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal modelsProc. Natl. Acad. Sci. USA107(34)15229-15234(2010)