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Pomolic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomolic acid图片
规格:98%
分子量:472.7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Randialic acid A (Pomolic acid) 是一种五环三萜烯,是从 Euscaphis japonica 中分离出来的。Randialic acid A (Pomolic acid) 抑制肿瘤细胞的生长并诱导细胞凋亡。 Randialic acid A (Pomolic acid) 有用于前列腺癌的潜力。
货号:ajcx33810
CAS:13849-91-7
分子式:C30H48O4
分子量:472.7
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC)[2].

Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9[2].

[1]. GuimarÃes LPTP, et al. Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells.Oncol Rep. 2017 Oct;38(4):2525-2534.
[2]. Park JH, et al.Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.Molecules. 2018 Sep 3;23(9). pii: E2236.