IU1-248 是 IU1 的衍生物，是一种有效的、选择性的 USP14 抑制剂，其 IC50 为 0.83 μM。
货号:ajcx34878
CAS:2307472-03-1
分子式:C20H23N3O2
分子量：337.42
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.