THK-5470，一种 monoamine oxidase-B(MAO-B) 成像探针，可用于 neurological diseases 研究。THK-5470 对 MAO-B 具有非常高的结合亲和力，IC50 值为 4.2 nM，对 tau 的结合亲和力较低，IC50 值为 4462 nM。THK-5470 具有高选择性结合性能和高亲和力，来自专利 EP2019-846498。
货号:ajcx35264
CAS:2410554-04-8
分子式:C18H17FN2O2
分子量：312.34
溶解度:DMSO : 100 mg/mL (320.16 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

THK-5470, a monoamine oxidase-B (MAO-B) imaging probe, could be used for neurological diseases study. THK-5470 shows remarkably high binding affinity against MAO-B with an IC50 value of 4.2 nM, low binding affinity against tau with an IC50 value of 4462 nM. THK-5470 has high selective binding property and high affinity (from patent EP2019-846498).