Elevenostat (JB3-22) 是一种选择性 HDAC11 抑制剂 (IC50=0.235 µM)。抗多发性骨髓瘤 (MM) 活性。
货号:ajcx37138
CAS:1454902-97-6
分子式:C16H17N3O4
分子量：315.32
溶解度:DMSO : 250 mg/mL (792.85 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235 µM). Anti-multiple myeloma (MM) activity[1].

[1]. Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17. [2]. Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713. Published 2021 Dec 22.