MSDC-0602K (Azemiglitazone potassium) 是一种噻唑烷二酮类化合物，与 PPARγ 结合，IC50 为 18.25 μM。MSDC-0602K 调节线粒体丙酮酸载体 (MPC)。MSDC-0602K 可用于脂肪肝的研究，包括功能失调的脂质代谢、炎症和胰岛素抵抗。MSDC-0602K 是一种胰岛素 (insulin) 增敏剂，单独或与 Liraglutide 联合使用可改善小鼠的胰岛素血症和脂肪肝疾病。
货号:ajcx37600
CAS:1314533-27-1
分子式:C19H16KNO5S
分子量：409.5
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MSDC-0602K (Azemiglitazone potassium), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC50 of 18.25 μM[1]. MSDC-0602K modulates the mitochondrial pyruvate carrier (MPC). MSDC-0602K can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance[2]. MSDC-0602K, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide[3].

Diabetic db/db and MS-NASH mice are treated with MSDC-0602K by oral gavage, Liraglutide by s.c. injection, or combination MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis (NASH).

[1]. Zhouji Chen, et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48.
[2]. Jerry R Colca, et al. MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis. Expert Opin Investig Drugs. 2018 Jul;27(7):631-636.
[3]. Dakota R Kamm, et al. Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. Jan-Jun 2021;296:100807.