MCC 是一种不可降解的 (non-cleavable) ADC 连接子，可用于合成 ADC，如 MCC-DM1。
货号:ajcx37678
CAS:104676-09-7
分子式:C12H16N2O3
分子量：236.27
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1].

Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1].

[1]. Polson AG, et al. Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia. 2010;24(9):1566-1573.