TMX-4113 是磷酸二酯酶 6D (PDE6D) 和酪蛋白激酶 1α (CK1α) 的降解剂。TMX-4113 可用于癌症研究。
货号:ajcx38076
CAS:N/A
分子式:C12H12N4O2S2
分子量：308.38
溶解度:DMSO : 100 mg/mL (324.28 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1].

TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells[1].TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) induces degradation of PDE6D in MOLT4 cells[1].TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells[1].

[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.