Tacrine 是一种有效的乙酰胆碱 (AChE) 抑制剂 (IC50=109 nM)，同时也是一种 CYP1A2 底物药物。Tacrine 在某些个体中表现出一定的肝毒性。Tacrine 可用于阿尔兹海默症的研究。
货号:ajcx38482
CAS:321-64-2
分子式:C13H14N2
分子量：198.26
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate drug. Tacrine exhibits certain hepatotoxicity in some individuals. Tacrine can be used for researching Alzheimer's disease (AD)[1][2][3].

[1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335.
[2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2.
[3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922.