GNE-375 是一种有效且高度选择性的 BRD9 抑制剂，IC50 为 5 nM。GNE-375 对 BRD9 的选择性比 BRD4、TAF1 和 CECR2 高 100 倍以上。GNE-375 降低 BRD9 与染色质的结合。
货号:ajcx39362
CAS:1926989-06-1
分子式:C25H29N3O5
分子量：451.51
溶解度:DMSO : 50 mg/mL (110.74 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin[1].

[1]. Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541.

Protocol:

BRD9 5nM(IC50)