AMG 333是有效，高选择性的 TRPM8 拮抗剂，IC50为13 nM。
货号:ajcx39918
CAS:1416799-28-4
分子式:C20H12F5N3O4
分子量：453.32
溶解度:DMSO : ≥ 125 mg/mL (275.74 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.

[1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.