CM10 是一种有效的，选择性乙醛脱氢酶 1A 家族抑制剂 (ALDH1Ai)，对于 ALDH1A1，ALDH1A2 和 ALDH1A3 的 IC50 分别为 1700、740 和 640 nM。CM10 对 ALDH 家族其他成员没有抑制作用。CM10 可以调节新陈代谢并具有抗癌活性。
货号:ajcx16206
CAS:692269-09-3
分子式:C20H23N3O
分子量：321.42
溶解度:DMSO: 125 mg/mL (388.90 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1].

[1]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.