FW1256 是一种苯基类似物，也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性，并可诱导细胞凋亡 (apoptosis)，并可用于癌症，炎症和心血管疾病的研究。
货号:ajcx16524
CAS:117089-08-4
分子式:C12H10NOPS
分子量：247.25
溶解度:DMSO: ≥ 250 mg/mL (1011.12 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activities and induces cell apoptosis. FW1256 has the potential for cancer, inflammation, and cardiovascular disease treatment[1][2].

[1]. Huang CW, et al. A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo. Pharmacol Res. 2016 Nov;113(Pt A):533-546. [2]. Feng W, et al. Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity. J Med Chem. 2015 Aug 27;58(16):6456-80.