2BAct 是一种具有高选择性的，可血脑屏障的，具有口服活性的真核起始因子 eIF2B 活化剂，EC50 为 33 nM。2BAct 可防止由慢性综合应激反应引起的神经系统缺陷。
货号:ajcx17324
CAS:2143542-28-1
分子式:C19H16ClF3N4O3
分子量：440.8
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2BAct is a highly selective, CNS-permeable, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response[1].

[1]. Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9.