DY 268 是一种法尼醇 X 受体 (FXR) 拮抗剂（在时间分辨 FRET 试验中，IC50\u003d7.5 nM）。
货号:ajcx20386
CAS:1609564-75-1
分子式:C30H32N4O5S
分子量：560.7
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DY 268 is a farnesoid X receptor (FXR) antagonist (IC50 = 7.5 nM in a time-resolved FRET assay).[1] It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.

参考文献:
[1]. Yu, D.D., Lin, W., Forman, B.M., et al. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg. Med. Chem. 22(11), 2919-2938 (2014).