An inhibitor of Rab27a-JFC1 protein-protein interactions
货号:ajcx20692
CAS:331949-35-0
分子式:C15H16N4O3
分子量：300.3
溶解度:15mg/mL in ethanol, 30mg/mL inn DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.

参考文献:
[1]. Johnson, J.L., Ramadass, M., He, J., et al. Identification of neutrophil exocytosis inhibitors (nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: Druggability of the small GTPase Rab27a. J. Biol. Chem. 291(50), 25965-25982 (2016).