A neuropeptide with diverse biological activities
货号:ajcx21134
CAS:N/A
分子式:C20H26D4O5
分子量：354.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

15-keto Prostaglandin E₂-d₄(15-keto PGE₂-d₄) is intended for use as an internal standard for the quantification of 15-keto PGE₂by GC- or LC-MS. 15-keto PGE₂is a metabolite of PGE₂formed by 15-hydroxy PGDH.^1,2In vivo, 15-keto PGE₂is essentially inactive. 15-keto PGE₂has reduced affinity for the EP₂and EP₄receptors (K_is = 2,600 and 15,000 nM, respectively) compared to PGE₂(K_is = 53 and 7.3 nM for the EP₂and EP₄receptors, respectively).³

1.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 2.Mak, O.T., Liu, Y., and Tai, H.H.Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidneyBiochim. Biophys. Acta1035(2)190-196(1990) 3.Nishigaki, N., Negishi, M., and Ichikawa, A.Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonistMol. Pharmacol.50(4)1031-1037(1996)