A neuropeptide with diverse biological activities
货号:ajcx22888
CAS:N/A
分子式:C51H65N13O15.XCF3COOH
分子量：1100.1
溶解度:Formic Acid: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH₂is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26.^1,2Upon cleavage by MMP-1, MMP-3, or MMP-26, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

1.Park, H.I., Turk, B.E., Gerkema, F.E., et al.Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26J. Biol. Chem.277(38)35168-35175(2002) 2.KnÄuper, V., Patterson, M.L., Gomis-RÜth, F.X., et al.The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivityEur. J. Biochem.268(6)1888-1896(2001)