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Tianeptine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tianeptine-d6图片
规格:98%
分子量:443
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23614
CAS:N/A
分子式:C21H19D6ClN2O4S
分子量:443
溶解度:Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tianeptine-d6is intended for use as an internal standard for the quantification of tianeptine by GC- or LC-MS. Tianeptine is an atypical antidepressant.1It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system.1,2Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs.3It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice.4It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.5It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.6


1.McEwen, B.S., Chattarji, S., Diamond, D.M., et al.The neurobiological properties of tianeptine (Stablon): From monoamine hypothesis to glutamatergic modulationMol. Psychiatry15(3)237-249(2010) 2.Gassaway, M.M., Rives, M.L., Kruegel, A.C., et al.The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonistTransl. Psychiatry4e411(2014) 3.Samuels, B.A., Nautiyal, K.M., Kruegel, A.C., et al.The behavioral effects of the antidepressant tianeptine require the mu-opioid receptorNeuropsychopharmacology42(10)2052-2063(2017) 4.Svenningsson, P., Bateup, H., Qi, H., et al.Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptineEur. J. Neurosci.26(12)3509-3517(2007) 5.Reagan, L.P., Rossell, D.R., Wood, G.E., et al.Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptineProc. Natl. Acad. Sci. U.S.A.101(7)2179-2184(2004) 6.Reznikov, L.R., Grillo, C.A., Piroli, G.G., et al.Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: Differential effects of antidepressant treatmentEur. J. Neurosci.25(10)3109-3114(2007)